Ecotoxicology of hexavalent chromium in fish: An updated review
Science of The Total Environment(2023)
摘要
Chromium (Cr) is prevalently found in trivalent and hexavalent forms. Though the former is toxicologically benign due to its poor cellular permeability, hexavalent chromium i.e. Cr [VI] crosses the biological membrane and induces toxic effects in organisms. While Cr [VI] toxicity in humans is a subject of occupational exposure at industries involved in ferrochrome production, leather tanning, textile dyeing etc., aquatic abundance of Cr [VI] due to discharge of Cr-laden effluents by these industries lead to extensive toxicity in piscine species. The present review aims to discuss the mode of Cr [VI] entry in fish and the several inimical effects that it imparts on fish health. Such effects have been reported in various studies through behavioral, hormonal and hematological alterations. Bio-accumulation of Cr [VI] in vital organs and subsequent perturbation of the oxidative homeostasis leads to organotoxic effects like changes in organo-somatic indices and histo-architecture. At cellular level, Cr [VI] induced genotoxicity is often found to trigger cellular demise including apoptosis. This review also highlights the stress response in fish against Cr [VI] induced toxicity that is mediated through the expressional alteration of a myriad of anti-oxidant and xenobiotic-metabolizing proteins which is, in turn, a function of activated transcription programs including the Nrf2-ARE pathway.
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关键词
Oxidative stress,Organo-toxicity,Genotoxicity,Apoptosis,Nrf2- Keap1 pathway
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