Neural stem cell-derived extracellular vesicles mitigate Alzheimer’s disease-like phenotypes in a preclinical mouse model

Dear Editor, Alzheimer's disease(AD)is the most common neurodegenera-tive disorder and the No.1 cause of dementia in elderly with no effective treatments.1 The application of stem cell-derived extracellular vesicles(EVs)has emerged as a promising therapeutic strategy for AD.2 EVs are small bilipid layer-enclosed vesicles that display blood-brain barrier(BBB)penetrating ability and similar potency to their parental cells.2 The administration of EVs derived from neural stem cells(NSCs)and mesenchymal stem cell(MSCs)improved learning and memory functions of AD mice after EVs injection.