Dioxygen Binding Is Controlled by the Protein Environment in Non-heme Fe^II and 2-Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene-Forming Enzyme

The cover shows the oxygen diffusion channel in class 7 histone demethylase (PHF8) and ethylene-forming enzyme (EFE). PHF8 catalyzes the hydroxylation of its H3 K9me2 histone substrate, and EFE catalyzes two competing reactions of ethylene generation and substrate l-Arg hydroxylation. Although both enzymes initially have an off-line 2-oxoglutarate (2OG) conformation, upon oxygen binding, PHF8 forms an in-line superoxo complex, whereas EFE uses the off-line superoxo complex. More information can be found in the Research Article by C. Z. Christov and co-workers. (DOI: 10.1002/chem.202300138).