Purine Nucleosides and Analogues Bearing Chiral Substituents: Medicinal Chemistry and Therapeutic Perspective.
Current medicinal chemistry(2024)
摘要
Adenosine and its analogues play an important role as bioregulators of metabolic processes in animal cells, affecting a variety of metabolic functions by acting through the purinergic signaling system. Synthesis and structure-activity relationship for some known purine nucleosides bearing chiral substituents are considered in this work. These compounds represent a promising potential as drug prototypes for targeted therapy of cancer, metabolic dysfunctions, and neuronal disorders due to their enhanced selectivity to receptors of the purinergic signaling system. Derivatives of adenosine and guanosine containing a chiral substituent also manifest antiviral activity.
更多查看译文
关键词
Adenosine receptors,purinergic signaling,adenosine,chirality,enantiomeric,antiviral,trans-glycosylation,enzyme
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要