Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria
Clinical Biochemistry(2023)
Abstract
•Volumetric absorptive microsampling (VAMS) dried blood method for blood phenylalanine measurement.•Validation of bioanalytical method in compliance with regulatory guidance.•Correlation analysis of VAMS dried blood method with plasma method.•Application in clinical study to support primary efficacy endpoint.
MoreTranslated text
Key words
Phenylalanine (Phe), Dried blood spot (DBS) sampling, Volumetric absorptive microsampling (VAMS), Phenylketonuria (PKU), PTC923 (sepiapterin), Validation
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined