IGFBP7 on the road to heart failure: driver or passenger?

Nature Cardiovascular Research（2022）

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摘要

Increasing evidence suggests that IGFBP7 may be an accurate biomarker for heart failure. A new study shows that beyond its diagnostic value, IGFBP7 may drive the detrimental effects of pressure overload in mice by a mechanism that, at least in part, involves the regulation of senescence by an IGF-1R–IR–FOXO3a signaling cascade.

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关键词

Extracellular signalling molecules,Heart failure,Cardiovascular Biology

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