Identification of molecular subtypes based on liquid-liquid phase separation and cross-talk with immunological phenotype in bladder cancer.

Le Sun,Xiao-Ping Liu,Xin Yan,Shaojie Wu,Xiaoyu Tang,Chen Chen,Gang Li,Hankun Hu,Du Wang,Sheng Li

Frontiers in immunology（2022）

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摘要

Our study identified a novel categorization of BLCA patients based on LLPS. The LLPSRS could predict the prognosis of patients and aid in designing personalized medicine. Further, our binary classifier could effectively predict patients' sensitivity to immunotherapy.

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关键词

bladder cancer,cytotoxicity,immunotherapy,liquid-liquid phase separation,machine learning,molecular subtypes,tumor microenvironment

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