Electrocardiogram Belt guidance for left ventricular lead placement and biventricular pacing optimization
Heart rhythm(2023)
摘要
BACKGROUND Patients with ischemic cardiomyopathy, non-left bundle branch block, or QRS duration ,150 ms have a lower response rate to cardiac resynchronization therapy (CRT) than did other indicated patients. The ECG Belt system (EBS) is a novel sur -face mapping system designed to measure electrical dyssynchrony via the standard deviation of the activation times of the left ventricle. OBJECTIVES The objectives of this study were to evaluate the effi-cacy of the EBS in patients less likely to respond to CRT and to deter-mine whether EBS use in lead placement guidance and device programming was superior to standard CRT care.METHODS This was a prospective randomized trial of patients with heart failure and EBS-guided CRT implantation and programming vs standard CRT care. The primary end point was relative change in left ventricular end-systolic volume from baseline to 6 months postim-plantation.RESULTS A total of 408 patients from centers in Europe and North America were randomized. Although both patients with EBS and control patients had a mean improvement in left ventricular end-systolic volume, there was no significant difference in relative change from baseline (P 5 .26). While patients with a higher base-line standard deviation of the activation times derived greater left ventricular reverse remodeling, improvement in electrical dyssyn-chrony did not correlate with the extent of reverse remodeling.CONCLUSION The findings of the present study do not support EBS guided therapy for CRT management of heart failure with reduced ejection fraction.
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关键词
Cardiac resynchronization therapy,SDAT,Electrocar-diographic imaging,Heart failure
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