Current approaches to evaluation and preservation of ovarian reserve in adolescent girls with premature ovarian insufficiency

Current approaches to evaluation and preservation of ovarian reserve in adolescent girls with premature ovarian insufficiencyThe prevalence of premature ovarian insufficiency (POI) is progressively increasing and has now reached 4.0% among the European population of women under the age of 40.In the pubertal period, the problem of reducing the ovarian reserve is also not uncommon.The most common cause of POI in this age group is genetic abnormalities, viral diseases and the influence of environmental factors.The frequency of iatrogenic POI in children is increasing due to an increase in survival rate of up to 80% after oncological treatment.To date, there is no clear determination by stages, criteria for the diagnosis of POI for the adolescent period.The peculiarity of adolescent patients with POI, in contrast to the older age group, is the absence of vasomotor symptoms and vulvovaginal atrophy in most girls, in all girls the above complaints were noted against the background of secondary amenorrhea after at least 6 months of regular menstruation with menarche.The study of intraovarial control of early folliculogenesis allowed us to develop innovative approaches in the treatment of POI, in particular, the method of activation of «sleeping» follicles.In addition to the generally recognized ones (cryopreservation of ovarian tissue, vitrification of oocytes and ovarian transposition), pharmacological drugs can be an attractive option for preserving fertility and activating residual follicles including the use of myo-and D-chiroinositol.It is necessary to further improve the existing and develop new technologies for preserving the fertility of patients at risk of POI developing.