Protective Effect of Moringa Oleifera Lam. Leaf Extract Against Oxidative Stress, Inflammation, Depression, and Apoptosis in a Mouse Model of Hepatic Encephalopathy
Environmental Science and Pollution Research(2022)
摘要
The present study aimed to assess the antioxidative, anti-inflammatory, antiapoptotic, and anti-depression impacts of Moringa oleifera Lam. leaf ethanolic extract (MOLE) in the hippocampus and cerebral cortex of CCl 4 -induced hepatic encephalopathy mouse model. High-performance liquid chromatography was used to detect marker compounds: rutin and β-sitosterol. Animals were divided into four groups: vehicle group, CCl 4 -treated group, MOLE-treated group, and (CCl 4 + MOLE) group treated with MOLE for 14 days before CCl 4 -induced neurotoxicity. MOLE decreased alanine aminotransferase, aspartate aminotransferase, corticosterone, and ammonia levels in serum and improved the antioxidant status of CCl 4 -treated mice in the hippocampus and cerebral cortex. It reduced the expression of toll-like receptor 4 (TLR4), TLR2, myeloid differentiation primary response 88 (MYD88), and nuclear factor-kappa B (NF-κB) genes and the protein levels of the pro-inflammatory cytokines. MOLE also attenuated apoptosis, as revealed by the reduced expression of caspase3, and prevented histological deterioration. Furthermore, MOLE attenuated CCl 4 -induced anxiety and depression-like behavioral changes. Collectively, MOLE modulates neuroinflammation, oxidative stress, TLR4/2-MyD88/NF-κB signaling, and apoptosis in the hippocampus and cerebral cortex of the hepatic encephalopathy experimental model.
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关键词
Behavioral changes,Hepatic encephalopathy,Inflammation,Moringa oleifera Lam.,Neuroprotection,TLR4/2-MYD88/NF-κB pathway
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