Structure revision and chemical synthesis of ligandrol's main bishydroxylated long-term metabolic marker.
ORGANIC & BIOMOLECULAR CHEMISTRY(2022)
Abstract
Although the main bishydroxylated long-term metabolite of the WADA-banned anabolic agent ligandrol (LGD-4033) is an important metabolic marker, it is not readily available in sufficient quantities to facilitate the development and validation of related analytical protocols or sensors. A chemically more robust structure was postulated as an alternative to the one previously established. The NMR spectra of the synthesized material and its LC-HRMS comparison with a relevant metabolic sample support the proposed structural revision.
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Key words
ligandrol,chemical synthesis,metabolic,long-term
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