Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.

Na Zhang,Shiguang Cao,Ruiying Sun, Yibei Wang, Luna Liu,Wei Wang,Xia Meng

PeerJ（2022）

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摘要

SPC21 plays a tumor suppressor role in LUAD cells by targeting the PTEN-PI3K/Akt axis and might be used as a prognostic indicator and therapeutic target in LUAD patients.

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关键词

Akt,Lung adenocarcinoma,PTEN,SPC21

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