Recovery from amblyopia with cholinesterase inhibition

An elevated threshold for neuroplasticity limits visual gains with treatment of residual amblyopia in late childhood and adulthood. Donepezil, an acetylcholinesterase inhibitor, can enable visual neuroplasticity and promote recovery from amblyopia in adult mice. Motivated by these promising findings, we sought to determine whether donepezil can enable recovery in older children and adults with residual amblyopia.