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Case Report: Senescence As Mechanism of Resistance to Pembrolizumab in a Lymphoma Patient Who Failed CD19-Targeted CAR-T Cell Therapy

Serena De Matteis,Beatrice Casadei,Ginevra Lolli,Michele Dicataldo,Francesco Barbato,Elisa Dan,Andrea Paccagnella,Barbara Sinigaglia,Clara Bertuzzi,Annalisa Arcari,Luca Zazzeroni,Patrizia Bernuzzi,Noemi Laprovitera,Gianluca Storci,Salvatore Nicola Bertuccio,Manuela Ferracin,Massimiliano Bonafe,Pier Luigi Zinzani,Francesca Bonifazi

Frontiers in immunology（2022）

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关键词
lymphoma,senescence,exhaustion,chimeric antigen receptor (CAR T),pembrolizumab,resistance
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