Β-C-glycosylation with 2-Oxindole Acceptors Via Palladium-Catalyzed Decarboxylative Reactions.
Organic letters(2022)
摘要
This report describes a highly efficient β-selective C-glycosylation of bicyclic galactals with 2-oxindoles through a palladium-catalyzed decarboxylative pathway. A variety of substrates representing both glycosyl donors and acceptors could be transformed in greater than 90% yields under mild reaction conditions. The decarboxylation intermediate of galactal could serve as an efficient base to deprotonate the enol tautomer of 2-oxindole and enhance its nucleophilicity. The β-selective nucleophilic addition at the anomeric center originates from the steric hindrance imposed by the palladium and bulky ligand.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要