Humoral cross-coronavirus responses against the S2 region in children with Kawasaki disease
Virology(2022)
Abstract
Multisystem Inflammatory Syndrome in Children (MIS-C), a post infectious complication of SARS CoV-2 infection, shares enough features with Kawasaki Disease (KD) that some have hypothesized cross-coronavirus (CoV) immunity may explain the shared pathology. Recent studies have shown that humoral cross-reactivity of the CoVs, particularly of OC43, is focused on the S2 region of the Spike protein.
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Key words
Kawasaki disease,Multisystem inflammatory syndrome in children,SARS-CoV-2,Coronavirus,Cross-immunity,Coronary aneurysms
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