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LC/MS/MS assessment of changes in placental angiotensin I metabolism in preeclampsia.

Dominika Settner-Kołodziejska,Beata Bujak-Giżycka,Anna Wiśniewska,Magdalena Łomnicka,Michał Kołodziejski,Marcin Wiecheć,Krzysztof Rytlewski,Hubert Huras,Rafał Olszanecki

Folia medica Cracoviensia（2022）

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Abstract
Production of Ang 1-7 by PE placentas was significantly lower than in control group. Significantly decreased mRNA expression of ACE and AT1 receptor and lower production of Ang II in placentas of PE patients suggest that placental Ang II/ACE/AT1r pathway could be less important than Ang 1-7/ACE-2/MASr pathway in development of preeclampsia, but this requires further investigations.
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Key words
RAS,angiotensin,angiotensinogen metabolism,placenta,preeclampsia
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