Current problems of the diagnostics and treatment of purulent-inflammatory diseases and sepsis

A deep understanding of the pathogenesis is the key point in the formation of diagnostic strategies and treatment tactics for patients with various diseases. In this paper, the thorough analysis of the microscopic processes that occur in the bodies of patients with purulent-septic diseases was carried out. The pathogenetic concept of the diagnostic and treatment model of purulent-inflammatory diseases and sepsis was proposed and presented. It is based on the fact that in diseases accompanied by endogenous intoxication, part of the albumin molecules in the blood of patients are blocked by toxins. However, the presence of albumin in the blood does not always reflect the completeness of its transport function. Its binding centers can be blocked by toxic ligands, due to which the transport capacity is sharply reduced. As a result, there are two types of albumin molecules in the blood: normal (concentration: X) and blocked by toxins /pathological (concentration: 1-X). So, pathological albumin molecules lose the ability to perform their basic functions, namely transport and detoxification. This allows us to assume that the presence of albumin and its functional state can influence the course of burn disease and the development of sepsis. The proposed diagnosis of sepsis consists in definition of Х*, i.e. the maximum minimum value of the concentration of albumin in patients with sepsis. If Х is more than Х*, this ensures the viability of the organism to some extent. Modern complex diagnostics, including early, within the framework of the method of fluorescence spectroscopy and biomarkers of purulent-septic diseases, and effective methods of their treatment and modern effective control of the treatment process are proposed.