The drug titration paradox: more drug does not correlate with more effect in individual clinical data.
British journal of anaesthesia(2022)
摘要
The relationship between drug dose and drug effect must be determined under carefully controlled experimental conditions. In routine care, where the effect is profoundly influenced by varying clinical conditions and drugs are titrated to achieve the desired effect, it is nearly impossible to draw meaningful conclusions about the relationship between dose and effect.
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关键词
alfentanil,drug titration paradox,feedback control,pharmacodynamics,pharmacokinetics,titration
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