Melamine induced human serum albumin aggregates: Its possible role in amyloidogenesis
Journal of Molecular Liquids(2022)
摘要
•Effect of MM over HSA in an in vitro manner was investigated.•HSA (15 μM) was incubated for 6 days at 65 °C. 30–225 μM MM was used in the study.•MM showed increase in fluorescence intensity with the increasing MM concentration.•Molecular docking and simulation studies were performed to understand the interacting residues.•Maximum induction was found to be in presence of 225 μM of melamine.
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关键词
Protein aggregation,Human serum albumin,Melamine,Adulterant,Amyloid fibrils,Neurodegenerative diseases
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