Study of the Protective Role of Zn in Cultured Retinal Pigment Epithelial Cells Subjected to Pro-Inflammatory Conditions Using Transcriptomics and Mass Spectrometry

Marta Aranaz,Ana Álvarez-Barrios,Marta Costas-Rodríguez,Lara Lobo,Lydia Álvarez,Héctor González-Iglesias,Rosario Pereiro,Frank Vanhaecke

Microchemical journal（2022）

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摘要

•Differential gene expression and Zn elemental & isotopic composition are investigated.•0.03 ‰ precisions for δ66Zn were reached in 20 μg/L solutions & dry plasma conditions.•At RNA level, pro-inflammatory events resulted in strong immune & cytokine responses.•Inflammation demonstrated to lead to a lighter Zn isotopic composition.

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关键词

Transcriptomics,Elemental & isotopic analysis,Cell culture,Mass spectrometry,Inflammation processes,Zn supplementation

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