Clinicopathologic Significance of Her-2 and P53 Expressions in Gastric Cancer.

Background: To detect the expression of HER-2 and P53 patients with gastric cancer and to analyze their correlation. Methods: A total of 249 gastric cancer patients with complete clinical data who received surgical treatment from China-Japan Union Hospital of Jilin University were selected. The expression of Her-2 and P53 were detected by immunohistochemistry using the streptavidin-biotin-peroxidase method. The correlations between HER-2 and P53 in gastric cancer were analyzed. Results: The positive rate of Her-2 and P53 expression was 37.3% (93/249) and 100% in all the specimens, respectively. The intensity of Her-2 expression was significantly different in patients with different degrees of gastric cancer cell differentiation (P 1/4 0.012). Meanwhile, the expression of her-2 was closely related to whether the pathological type of gastric cancer was a signet-ring cell carcinoma (P 1/4 0.022). Different percentage of positive P53 expression was closely related to the grade of tumor differentiation (P 1/4 0.035) and positive Ki67 expression (P 1/4 0.001). There was a significant positive correlation between HER-2 and P53 expression in gastric cancer (P 1/4 0.003). These findings suggest that HER-2 and P53 have synergistic effects in gastric cancer. Conclusion: Her-2 and P53 are important markers for invasion and metastasis of gastric cancer. Combined detection of P53 and Her-2 expression in gastric cancer tissue can be used to assess prognosis and screen cancer patients at high risk of metastasis. & COPY; 2022 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).