NSBB-associated VWF-decreases in decompensated cirrhosis indicate a reduced risk of further decompensation, ACLF, and death

M Jachs,L Hartl,B Simbrunner,D Bauer,R Paternostro,B Scheiner,P Schwabl,AF Stättermayer,M Pinter,E Eigenbauer,P Quehenberger,M Trauner,T Reiberger,M Mandorfer

Zeitschrift für Gastroenterologie54. Jahrestagung & 31. Fortbildungskurs der Österreichischen Gesellschaft für Gastroenterologie & Hepatologie – ÖGGH (Hybrid Veranstaltung)（2021）

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摘要

Background and Aims Bacterial translocation promotes endothelial dysfunction and systemic inflammation (SI), thereby driving disease progression in cirrhosis. Non-selective beta-blockers (NSBBs) may exert beneficial effects beyond lowering portal pressure.We assessed (i) NSBB-related changes in von Willebrand factor levels (VWF) and (ii) their prognostic value for outcomes in decompensated cirrhosis.

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关键词

cirrhosis,further decompensation,nsbb-associated,vwf-decreases

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