Synthesis and Properties of N , N ′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: XII. N -(1,3,3-Trimethylbicyclo[2.2.1]heptan-2-yl)- N ′-R-ureas and -thioureas

N , N ′-Disubstituted ureas and thioureas containing a lipophilic optically active bicyclic fragment of natural origin were synthesized by reaction of ( R )- and ( S )-1,3,3-trimethylbicyclo[2.2.1]heptan-2-amine (prepared from the natural terpenoid fenchone) with aromatic isocyanates and isothiocyanates in up to 88 and 87% yield, respectively, with the goal of assessing the enantiomeric specificity of human soluble epoxide hydrolase (hsEH). The synthesized compounds were found to be promising as inhibitors of RNA virus replication and hsEH.