Exploration of benzimidazoles as potential microtubule modulators: An insight in the synthetic and therapeutic evolution
Journal of Molecular Structure(2022)
Abstract
The dynamic microtubules are one of the most fruitful targets for cancer chemotherapy. The outcomes of various studies depict that the benzimidazole framework is a fundamental moiety in various synthetic analogues, signifying a myriad scope of therapeutic activities. These scaffolds have also established their place as prospective tubulin polymerisation inhibitors in the medicinal chemistry arena. In this regard, the current review demonstrates a comprehensive report on the design and synthetic strategies engaged in developing various benzimidazole-bearing heterocyclic molecules as promising cytotoxic agents acting as tubulin polymerisation modulators. The detailed assessment of antiproliferative activities with reference drugs allows a proficient assessment of the structure-activity relationships (SARs) of the diversely synthesised benzimidazole hybrids.
MoreTranslated text
Key words
Anticancer activity,Benzimidazole,Microtubule inhibitors,Structure-activity relationship,Molecular hybridization
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined