POS-773 CALCINEURIN INHIBITORS DOSAGE AND RESULTANT BLOOD TROUGH LEVELS ON DAY THREE AND SEVEN IN KIDNEY TRANSPLANT RECIPENTS IN KENYA: A SINGLE CENTRE OBSERVATION

Calcinerurin inhibitors (CNI) are immunosuppressive drugs which target intracellular signaling pathways by binding to distinct molecules. In kidney transplant recipients, the immunosuppressive medications typically include a calcineurin inhibitor, a glucocorticoid and antimetabolite. The commonest CNI molecules used are tacrolimus and cyclosporine. Tacrolimus is a macrolide antibiotic which inhibits T cell activation by inhibiting calcineurin. The recommended initial dose is 0.2mg/kg/day in two divided doses for adult kidney transplant recipients.