The IFNγ‐PDL1 Pathway Enhances the Interaction Between CD8+ T Cells and Distal Convoluted Tubules to Promote Salt‐Sensitive Hypertension

Activated CD8Ts demonstrate enhanced ability to interact with DCTs leading to increased expression of NCC and sodium retention through a IFNγ-PDL1 pathway mediated mechanism. Blocking the IFNγ-PDL1 pathway prevents CD8T-DCT interaction both in vitro and in vivo, thereby ameliorating salt-sensitive hypertension.