A One-Pot Synthesis of Disubstituted Thiazoles from Chalcone C-H Bonds, Elemental Sulfur, and Glycine Ethyl Ester
SYNLETT(2022)
摘要
A method for assembling chalcones, glycine ethyl ester hydrochloride, and elemental sulfur toward a synthesis of 4,5-disubstituted thiazoles is reported. The transformation presumably proceeds via a sequence of β-C–H amination, annulation, and dealkoxycarbonylation. This tactic represents a rare example of a method for obtaining such disubstituted thiazoles directly from chalcone C–H bonds.
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关键词
C-H bond functionalization,enaminones,sulfur,thiazoles,annulation
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