A One-Pot Synthesis of Disubstituted Thiazoles from Chalcone C-H Bonds, Elemental Sulfur, and Glycine Ethyl Ester

A method for assembling chalcones, glycine ethyl ester hydrochloride, and elemental sulfur toward a synthesis of 4,5-disubstituted thiazoles is reported. The transformation presumably proceeds via a sequence of β-C–H amination, annulation, and dealkoxycarbonylation. This tactic represents a rare example of a method for obtaining such disubstituted thiazoles directly from chalcone C–H bonds.