P33. Regular Cannabis Use Modulates the Impact of HIV on the Neural Dynamics Serving Cognitive Control in the Dorsolateral Prefrontal Cortex

Cannabis use and HIV are both associated with deficits in cognitive control. However, less is known regarding how HIV and regular cannabis use together affect neural dynamics within the dorsolateral prefrontal cortex (dlPFC), which is a critical region for cognitive control processing. We hypothesized that cannabis and HIV would interact, such that people with HIV (PWH) who regularly use cannabis would have weaker (i.e., more optimal) spontaneous theta activity and stronger (i.e., more optimal) oscillatory theta responses in the dlPFC compared to nonusers with HIV.