Nucleolin: a Binding Partner of G-quadruplex Structures
TRENDS IN CELL BIOLOGY(2022)
摘要
Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine-glycine-glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence that the nucleolin/G-quadruplex partnership is of extensive relevance to neurodegenerative disease, cancer, and viral infections.
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关键词
G-Quadruplexes
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