Activation of the unfolded protein response (UPR) and fibrosis is associated withcholangiocellular injury in an experimental model of fibropolycystic liver disease
Zeitschrift für Gastroenterologie38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber(2022)
摘要
Background&Aim Fibropolycistic liver disease is characterized by hyperproliferation of the biliary epithelium and the formation of multiple dilated cysts, a process recently associated with unfolded protein response (UPR). In the present study, we aimed to understand the mechanisms of cyst formation and UPR activation of hepatocyte-specific c-Jun N-terminal kinase 1/2 (Jnk1/2) knockout mice.
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关键词
fibropolycystic liver disease,withcholangiocellular injury,liver disease,fibrosis,protein response
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