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The genomic mutational landscape and its correlation with TMB, PD-L1 expression and CD8+ T cell infiltration in Chinese lung large cell neuroendocrine carcinoma

Ye Li,Xinying Shi,Beibei Mao,Lingxiong Wang,Lijia Wu,Jie Li,Shunchang Jiao

Lung Cancer（2022）

Cited 2|Views12
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Abstract
•High CD8 + T cell infiltration in stroma region was a favorable factor for DFS.•Combination targeted therapy may be a potential option for resectable LCNECs.•Stratify patients based on KEAP1 mutation status and stromal PD-L1 expression.
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Key words
CI,DFS,HR,LCNEC,LUAD,LUSC,Multi IHC,NSCLC,OS,PD-L1,PD-1,RFS,SCLC,TMB,TIME,WES
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