Effects of Irbesartan on ATPase Activity and Angiotensin II in Blood Vessel from Renal Hypertensive Rats
Chinese Journal of Hypertension(2010)
Abstract
Objective To explore the effects of Irbesartan on activities of Na+-K+-ATPase,Ca2+-ATPase,Angiotensin Ⅱ(Ang Ⅱ)and vascular remodeling in renal hypertensive rats(RHR).Methods Renovascular hypertension was induced by two kidney-one clip method.Eighteen RHR were randomly divided into 3 groups: RHR model group(n=6),Irbesartan treated group [50 mg/(kg·d),n=6],withdrawal group(n=6).Six rats were included in sham operation group.Blood pressure(BP) was measured before and after using irbesartan.Thicknesses of vascular wall(TVW) of thoracic aorta and mesenteric artery were measured after 8 weeks.ATPase activities were determined by enzymatic colorimetric method.Ang Ⅱ level was determined by radioimmunoassay.ResultsCompared to the sham operation group,BP,TVW,Ang Ⅱ of plasma and blood vessel were increased in RHR.The activities of Na+-K+-ATPase,Ca2+-ATPase were decreased in RHR.BP,TVW of mesenteric artery were significantly decreased by irbesartan treatment.An increased Ang Ⅱ level and activity of Ca2+-ATPase in thoracic aorta and mesenteric artery was also found.No change the activity of Na+-K+-ATPase was found after irbesartan treatment.One week after discontinuation of treatment,BP was significantly elevated,the activity of Ca2+-ATPase of thoracic aorta was decreased(both P0.01),There was a significant negative correlation between Ang Ⅱ and the activity of Ca2+-ATPase in RHR.Conclusion The vascular remodeling of RHR may be associated with decreased vascular ATPases activities.Irbesartan can reverse vascular remodeling partially by increasing Ca2+-ATPase activity.
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Key words
renal hypertensive rats,angiotensin ii,atpase activity,irbesartan
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