18F-FDG pet studies correlate with the MOCA test in parkinson’s disease in a Han Chinese Cohort

Background: Parkinson’s disease(PD) with or without dementia become a popular topic, the changing of this cognitive function have detected by using 18 F-fluorodeoxyglucose(FDG) and Positron Emission Tomography(PET). In addition, different ethnic groups should be reported about this.The objective of this study was to detect the metabolic changes of different Montreal Cognitive Assessment (MOCA) state by using in PD in a Han Chinese cohort. Methods: Fifty PD patients and twenty healthy controls were invited to participate in this study. All people underwent MOCA test and 18 F-FDG PET, then use SPM8 to analyze the characteristics of the metabolism in different cognitive state in PD patients. Results: The PD-MCI patients showed hypometabolism in temporal, parietal lobe and occipital lobe and a less extent in the frontal and limbic lobes compared with control, and to a lesser extent in frontal, temporal and parietal lobes compared with PD-NC. The PDD patients exhibited an extensive bilateral hypometabolism in most cortical compared with control, and a lower metabolism mainly in frontal, temporal and occipital lobes with PD-MCI, however, widespread hypometabolism was seen in cortical and subcorticle compared with PD-NC. Conclusions: In a Han Chinese cohort, PD patients with MCI showed decreased metabolism mainly in post-cortical regions(tempora-parietal-occipital lobes) compared with control, and with the dementia happened, the hypometabolism region become larger and higher. The metabolism changing in post-cortical regions may become a biomarker for progression of PD cognitive impairment in Han Chinese cohorts.