Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease

The research was aimed at the investigation of systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease. We examined 42 patients with no clinical symptoms but at high risk of knee osteoarthrosis, and 12 donors with no musculoskeletal pathologies. It was established that systemic abnormalities featured by the negative change in the cell immunity along with pro-inflammatory cytokine activation were detectable even in the early stage of primary osteoarthrosis. These had probably facilitated the progress of the immune response followed by the inflammatory reaction that led to the progress of destructive changes in the connective tissue structures of the knees4 the process was proven by the increase in cartilage oligomeric matrix protein as well as cartilage glycoprotein-39.