Trametes Genus, a Source of Chemical Compounds with Anticancer Activity in Human Osteosarcoma: A Systematic Review

Natural bioactive compounds have aroused great interest for their potential benefits in human health, particularly in the prevention and treatment of cancer. The aim of this systematic review is to inspect whether bioactive compounds present in mushrooms of the genus Trametes have shown anticancer activity in human osteosarcoma. According to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) parameters, this review was carried out using Science Direct, PubMed Central, and Embase as electronic databases to select the articles that evaluated the cytotoxic effects of extracts or compounds isolated from mushrooms of the genus Trametes in human osteosarcoma. A total of 15 studies out of 165 met the inclusion criteria and are included in our systematic review. Among them, six studies evaluated extracts, eight evaluated polysaccharides, and one evaluated tetralin lignans of different species of the genus Trametes. Although only two research articles evaluated the effects of chemical compounds such as polysaccharides on human osteosarcoma, all of them have confirmed the potential of compounds present in mushrooms to treat different types of cancer.