[pp.02.13] effect of combination drug (arb irbesartan 100mg pulas ca-antagonist amlodipine 5mg or 10mg) on hypertensive patients

Objective: To determine the blood pressure lowering effect of combination drug ARBpulasCa-antagonist), we used Irbesartan/Amlodipine Besilate (Irbesartan 100 mg + amlodipine 5 mg, 10 mg) for the 46 hypertensive patients changes other antihypertensive drugs. Design and method: 46 patients (average age 67.5 ± 11.9years old, male 39, female 7). Before aimius administration, ARB treated patiens 19, CCB treated patiens 19, no treatment 8. They were treated by Irbesartan/Amlodipine Besilate for 12 weeks. Results: 12 weeks after treatment, Systolic blood pressure was from 157 ± 20 to 146 ± 17 mmHg and diastolic BP was from 96 ± 10 to 88 ± 9 mmHg (P < 0.001) in all 46 patients. In 19 Aimikus HD, SBP was from 159 ± 18 to 146 ± 17 mmHg (P = 0.005), DBP was 96 ± 8 to 88 ± 8 mmHg (P < 0.001). In 27 LD, SBP was from 159 ± 21 to 147 ± 18 mmHg (P = 0.027) and from 96 ± 11 to 86 ± 9 mmHg (P = 0.002). The clinical data was shown, LDL cholesterol (n = 42) 112 ± 32 to 105 ± 27 mg dl (P = 0.006)) HDL cholesterol (n = 42) 22 to 61 mg per dl (P = 0.002), HbAIC (n = 17) 6.6 ± 0.6 to 6.4 ± 0.5% (P = 0.005), Blood glucose 118 ± 25 mg/dl to 117 ± 26, eGHR (n = 41) from 59 ± 2 to 59 ± 2 ml/min. Conclusions: Combination drug (Irbesartan and amlodipine) was singnificalntly lowered high blood pressre before treatment without any side effect for lipid and glucone metabolism and renal function.