Hyperimmunglobulinämie E, Rezidivierende Staphylokokkeninfekte Und Granulozyten-Chemotaxis-Defekt Im Erwachsenenalter: Eine Variante Des Job-Syndroms
DMW - Deutsche Medizinische Wochenschrift(2008)
摘要
Two cases in adults with recurrent staphylococcal infections associated with abnormal granulocytic chemotaxis and hyperimmunoglobulinaemia E (Job's syndrome) are described. The pathophysiological mechanisms seems to consist of an abnormal IgE reaction against staphylococcal antigens causing secondary abnormality of granulocyte function. Abnormal cellular immune function was demonstrated in vitro and in vivo. Corticosteroid administration at first proved effective in both patients. One patient developed Hodgkin's disease of the mixed type in the course of the disease.
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