Transient Sox 9 Expression Facilitates Resistance to Androgen Targeted Therapy in 1 Prostate Cancer

Transient Sox9 Expression Facilitates Resistance to Androgen Targeted Therapy in 1 Prostate Cancer 2 3 Mannan Nouri1,2, Shabnam Massah1,2, Josselin Caradec1,2, Amy A. Lubik1,2, Na 4 Li1,2, Sarah Truong1, Ahn R. Lee1,2, Ladan Fazli1, Varune R. Ramnarine1,2, Jessica 5 M. Lovnicki1,2, Jackson Moore1, Mike Wang1, Jane Foo1, Martin E. Gleave1,2, Brett 6 G. Hollier3, Colleen Nelson1,2,3, Colin Collins1,2, Xuesen Dong1,2 and Ralph 7 Buttyan1,2* 8 9 1Vancouver Prostate Centre, Vancouver, Canada 10 2Department of Urologic Sciences, University of British Columbia, Vancouver, Canada 11 3Institute of Health and Biomedical Innovation, Queensland University of Technology, 12 Brisbane, Australia 13 14 Running Title: Transient Sox9 Facilitates Prostate Cancer Progression 15 16 *Corresponding Author: Ralph Buttyan; Vancouver Prostate Centre, 2660 Oak Street, 17 Vancouver, BC, Canada V6H-3Z6; Phone: (604)875-4111, ext21758; Fax: (604)87518 5654; E-mail: rbuttyan@prostatecentre.com 19 20 The authors declare no conflicts of interest. 21