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COMMUNICATION Monodisperse Polysarcosine-based Antibody-Drug Conjugates

Warren Viricel,Guy Fournet,Sabine Beaumel,Emeline Perrial,Sébastien Papot,Charles Dumontet,Benoît Joseph

semanticscholar（2021）

Cited 0|Views8
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Abstract
We report the on-resin synthesis of monodisperse (i.e. discrete) polysarcosine compounds and their uses as an hydrophobicity masking entity for the construction of highly-loaded homogeneous antibody-drug conjugates (ADC). The polysarcosinebased drug-linker platform described herein improves drug-loading, physicochemical properties, pharmacokinetics and shows excellent
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