Clinical, Meibographic, and Interferometric Evaluation in Children with Ocular Rosacea.

PURPOSE: To describe clinical, meibographic, and in-terferometric signs in children with ocular rosacea. DESIGN: Prospective case-control study. METHODS: This single-center study at the Fondation Ophtalmologique Rothschild (Paris, France) included 42 children with ocular rosacea and 44 healthy volunteers (median ages of 10 and 11 years old, respectively) who had infrared meibography images of their lower lids and tear lipid layer thickness measurements taken with the LipiView II device (Tearscience). Clinical severity was graded on a 0 to 4 scale and compared with meiboscores (range 0-4) and tear film lipid layer thickness (range 0100 nm). RESULTS: Seven patients presented with unilateral dis-ease and 29 had an asymmetrical form. Twenty-four pa-tients had associated cutaneous rosacea. Ten of 84 eyes presented with a loss of vision <20/25. The mean clinical severity grade was 2.5 +/- 1.4. Meibographic abnormalities were significantly more important in children with ocular rosacea (mean meiboscore 2.1 +/- 1.36) than in healthy volunteers (0.61 +/- 0.78, P <.001). Clinical severity (r = 0.44, P <.001), duration of disease (r = 0.28, P =.011), and a history of chalazia (r = 0.30, P =.006) were correlated to meibographic severity. Mean lipid layer thickness was not significantly different between cases and controls (74.4 +/- 18.7 nm and 76.6 +/- 18 nm, re-spectively, P =.47). CONCLUSION: Meibomian structural alterations in children can be severe and are correlated to ocular rosacea severity. Meibography is an essential tool for diagnosis and follow-up, whereas the contribution of tear film interferometry is uncertain. (C) 2021 Elsevier Inc. All rights reserved.)