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Differential regulation of lipopolysaccharide-induced IL-1β and TNF-α production in macrophages by palmitate via modulating TLR4 downstream signaling

Chunyun Fang,Lixia Wang,Jingting Qiao,Lina Chang,Qing He,Xiaona Zhang,Ming Liu

International Immunopharmacology（2022）

Cited 3|Views12
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Abstract
•PA differentially regulated LPS-induced expression of TNF-α and IL-1β.TLR4 downstream signalling was differentially regulated by PA.•Cellular oxidation of PA was necessary to induce these effects.
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Key words
TLR4,TNF-α,IL-1β,Palmitic acid,Macrophage
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