Convenient Method For Preparing Alpha-Ketoarylthioamide By Air Oxidation Under Base Conditions

A practical method for preparing alpha-ketoaryl thioamide by air oxidation has been developed. Under air atmosphere, in the presence of K2CO3 as base and dimethyl sulfoxide (DMSO) as solvent at 120 degrees C, a variety of alpha-ketoarylthioamides were obtained from aryl thioamide in yields of 42%similar to 85%. This reaction has good substrate applicability, metal-free and atomic economy, and provides an efficient, economical, green and convenient method for the synthesis of alpha-ketoaryl thioamide.