Platelet-Rich Fibrin-Induced Bone Marrow Mesenchymal Stem Cell Differentiation Into Osteoblast-Like Cells And Neural Cells
NEURAL REGENERATION RESEARCH(2011)
Abstract
Bone marrow mesenchymal stem cells were allowed to develop for 14 days in a platelet-rich fibrin environment. Results demonstrated that platelet-rich fibrin significantly promoted bone marrow mesenchymal stem cell proliferation. In addition, there was a dose-dependent increase in Runt-related transcription factor-2 and bone morphogenetic protein-2 mRNA expression, as well as neuron-specific enolase and glial acidic protein. Results showed that platelet-rich fibrin promoted bone marrow mesenchymal stem cell proliferation and differentiation of osteoblast-like cells and neural cells in a dose-dependent manner.
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Key words
alkaline phosphatase, bone marrow mesenchymal stem cells, glial fibrillary acidic protein, neural regeneration, neuron-specific enolase, platelet-rich fibrin
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