MP07-04 STONE FORMATION BY ANALYSIS OF UROFLOW DYNAMICS IN THE RENAL PELVIS

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology (MP07)1 Sep 2021MP07-04 STONE FORMATION BY ANALYSIS OF UROFLOW DYNAMICS IN THE RENAL PELVIS Kengo Kawase, Shuzo Hamamoto, Shota Hattori, Ryosuke chaya, Tomoki Okada, Yutaro Tanaka, Takeru Sugino, Rei Unno, Kazumi Taguchi, Ryosuke Ando, Atsushi Okada, Masanori Nakamura, and Takahiro Yasui Kengo KawaseKengo Kawase More articles by this author , Shuzo HamamotoShuzo Hamamoto More articles by this author , Shota HattoriShota Hattori More articles by this author , Ryosuke chayaRyosuke chaya More articles by this author , Tomoki OkadaTomoki Okada More articles by this author , Yutaro TanakaYutaro Tanaka More articles by this author , Takeru SuginoTakeru Sugino More articles by this author , Rei UnnoRei Unno More articles by this author , Kazumi TaguchiKazumi Taguchi More articles by this author , Ryosuke AndoRyosuke Ando More articles by this author , Atsushi OkadaAtsushi Okada More articles by this author , Masanori NakamuraMasanori Nakamura More articles by this author , and Takahiro YasuiTakahiro Yasui More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001980.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Previous studies have shown that Randall's plaques are uniformly present in all renal papillae. However, we experienced cases in which the kidney stone recurrence occurred in the same position and the same renal calices. Therefore, we focused on the effect of urinary flow caused by the morphology of the renal pelvis. In this study, we used urodynamic analysis to investigate the differences in stone formation related to the morphology of the renal pelvis. METHODS: Study 1: Investigation of the site of intervening kidney stones Among the patients who visited our hospital from June 2018 to August 2019, 177 patients, diagnosed with kidney stones using CT, were included in the study. The sites of interest to the study were the upper, middle, and lower renal calyx. Study 2: A simulation analysis of urine fluid. Overall, three kidneys with no stones (NS group) and three kidneys with stones (S group) were studied. 3D models were created from the renal pelvis images obtained from contrast-enhanced CT, and a simulation analysis was performed using computational fluid dynamics. Study 3: Measurement of urine flow and analysis of flow velocity distribution. The phase-contrast method was used to measure the flow in one kidney of a healthy subject, using MRI. A cut-off value was set based on the measurement results, and the distribution of urine flow velocity was analyzed based on the results of study 2. RESULTS: Study 1: The location of intervening kidney stones in the upper, middle, and lower renal calices tended to be in 22 (12%), 92 (52%), and 63 (36%) patients, respectively. Study 2: No vortex-like stream or stagnation was observed in the renal pelvis in both the NS and S groups. Study 3: The method showed the flow velocity in the renal pelvis to be 820 μm/s. The cut-off values for the PS method were set at 400 μm/s and 800 μm/s. In the NS group, the velocity distribution was uniform, but in the S group, there was a difference in velocity in each renal calice. CONCLUSIONS: There was no vortex-like stream or stagnation in the renal pelvis, but there was a difference in the velocity of urine flow depending on the site. In previous studies of crystal growth, the velocity of solute flow has been reported to affect the growth. Differences in urine flow velocity in the renal pelvis might be involved in stone formation. Source of Funding: The authors declare no conflicts of interest associated with this manuscript © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e140-e140 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kengo Kawase More articles by this author Shuzo Hamamoto More articles by this author Shota Hattori More articles by this author Ryosuke chaya More articles by this author Tomoki Okada More articles by this author Yutaro Tanaka More articles by this author Takeru Sugino More articles by this author Rei Unno More articles by this author Kazumi Taguchi More articles by this author Ryosuke Ando More articles by this author Atsushi Okada More articles by this author Masanori Nakamura More articles by this author Takahiro Yasui More articles by this author Expand All Advertisement Loading ...