The Effect Of Quercetin On Induction Of Apoptosis And Cell Proliferation In Experimental Rat Colon Carcinoma

Colon cancer is the fourth cause of mortality in the world and the second most common cancer in Europe (1). About 8% of overall mortality rate caused by cancer is caused by colon carcinoma and the highest spread of colon cancer is reported in Asia and Eastern Europe (2). Among cancer preventive factors by chemical mechanisms reducing risk of cancer, Phytochemicals CaO be the most effective factors. Among the Phytochemicals, one can refer to quercetin. Quercetin is the second flavonoid in plant species, which is available in fruits and the majority of vegetables (36) and can be considered as an important cancer prevention compound. The cancer preventive effects of the compound can be attributed to antioxidant activity of quercetin, inhibition of carcinogen activating enzymes, regulation of intercellular signal transfer paths and interaction of quercetin with receptors and other proteins (37). According to studies, quercetin can inhibit sulfate and hence, it can increase biofeedback and treatment competency through inhibition of sulfate.