Pathophysiological Body Reactivity and Interactions in Comorbidities. Synergism Versus Antagonism of Disease Pathways and Etiopathogenetic Clusters in Comorbidity Conditions.

Complexity, variability, nonlinearity and adaptive alterations in human health and disease are considered within the integral body physiology. Sokolić's principles and Koshland's pillars of life are referred as a conceptual frameworks for the whole-body performance. Disease pathways and etiopathogenetic clusters (EPCs) form networks. Due to EPCs, pathways and networks body reactivity gets reduced, and may lead to latent insufficiencies, a decompensation and death. Networking can be triggered by various etiologies. Overlapping of one disease network with the other simultaneous ones may lead to interferences of a disease development and manifestations. Comorbidity effects may be synergistic, and thus it leads to a more severe disease state. On the other side, antagonistic interaction of the two disease may lead to improvement and/or prevention. 20 comorbidities of each type are outlined in this paper.