Investigation Of Il6 Expression In Patients With Colorectal Adenocarcinoma

Introduction: It is well known that there is a complex correlation between inflammation and tumor development and tumor progression. Interleukin-6 (IL6) is a pleiotropic inflammatory cytokine with both tumor stimulating and inhibiting effect.Objective: The goal of our study was to evaluate the IL6 expression of histological slides from patients after resection of colorectal adenocarcinoma.Method: Demographical, surgical, and pathological findings of 64 patients with colorectal cancer operated between 2004 and 2011 in Uzsoki Teaching Hospital were evaluated. Histopathological slides were stained with IL6 antibody. The digitalized slides were assessed with quantitative color analysis, and the results were evaluated according to patients' clinical parameters.Results: Linear regression showed significantly higher IL6 expression in the tumor cells in patients with advanced stages. However, the IL6 expression of the tumor cells did not correlate with sex, age, or tumor grade.Discussion: There were differences between the IL6 expression in tumor cells and stromal cells. Conclusion: IL6 may be a useful marker and potential therapeutic target in patients with advanced colorectal cancer.