Resting State Connectivity Differentiates Asymptomatic Patients With Bipolar Disorder and Major Depressive Disorder

Bipolar Disorder (BD) is commonly misdiagnosed as Major Depressive Disorder (MDD) because depression declares onset and is common to both; making it imperative to identify neural mechanisms that can differentiate the two disorders clinically. Interrogating the resting brain may reveal core distinguishing abnormalities in its framework and thus we adopted an a priori approach; examining respectively three core mood disorder networks subserving executive function, salience and rumination, and differential neural connectivity between remitted BD and MDD patients.