Pos-319 emergency and critical healthcare resource utilisation of patients with chronic kidney disease according to severity of albuminuria: a report from the discover ckd retrospective cohort

Real-world data reporting healthcare resource utilization (HCRU) associated with CKD categorized according to severity of albuminuria, are scarce. DISCOVER CKD is an observational study in patients with CKD. Data was extracted using the US hospital based electronic medical record database; TriNetX and the UK primary care Clinical Practice Research Datalink (CPRD) linked to hospital data. Patients were aged ≥18 years, with ≥1 urine albumin-creatinine-ratio (UACR) measure and two estimated glomerular filtration rate (eGFR) measures of 0-75 mL/min/1.73 m2 recorded at least 90 days apart between January 2008 and September 2018. Index date was 2nd eGFR. Incidence rates per 100 person-years (PY) were estimated for critical care and emergency room visits. Preliminarily, 19,183 patients from TriNetX (mean [standard deviation] age of 65.0 [11.9] years, 55.1% female, median [interquartile range] eGFR 60.0 [49.9-68.6] and UACR 10.4 [4.5-30.1]) and 99,186 patients from CPRD (mean [SD] age 68.5 [11.3] years, 50.8% female, median [IQR] eGFR 64.0 [55.1-70.2] and UACR 15.9 [6.9-56.6]) met the inclusion criteria. Emergency room visits and critical care admissions were frequent and increased considerably with increasing UACR. Large differences were seen between emergency room visits and critical care admissions in the US and UK, Table 1. This analysis demonstrated that higher HCRU is seen in patients with increasing albuminuria, emphasizing the clinical and economic burden of CKD. These results highlight the need for innovative therapies to improve patient outcomes in this population.